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The chronic presence of biofilm-forming pathogens, combined with the sustained release of toxins and inflammatory mediators, creates an environment where the immune system is not able to resolve the infection effectively, leading to delayed wound healing, recurrent infections, and further tissue damage

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Study protocol of the GRoningen early-PD Ambroxol treatment (GREAT) trial: A randomized, double-blind, placebo-controlled, single center trial with ambroxol in Parkinson patients with a GBA mutation